What is Helicobacter pylori (HP) infection?

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What is Helicobacter pylori (HP) infection?​

Abstract Helicobacter pylori(H. pylori) infection is a common worldwide infection that is an important cause of peptic ulcer disease and gastric cancer.
What happens if you have H pylori in your stomach?
Ulcers. H. pylori can damage the protective lining of your stomach and small intestine. This can allow stomach acid to create an open sore (ulcer). About 10% of people with H. pylori will develop an ulcer. Inflammation of the stomach lining. H. pylori infection can irritate your stomach, causing inflammation (gastritis). Stomach cancer.

How effective is nonprescription therapy for H pylori infection?​

Overall, nonprescription therapy gives patients and physicians another option when faced with H pylori infection, and it has the benefit of helping to promote the balance of intestinal flora while having potentially fewer side effects than antibiotics. There are several natural agents that are good candidates for eradication of H pylori overgrowth.
What is Helicobacter pylori sensitivity to amoxicillin?
Helicobacter pylori is very sensitive to amoxicillin both in vivo and in vitro. Like other penicillins, amoxicillin works by inhibition of bacterial cell wall synthesis, leading to cell death.

These low rates of successful treatment are not acceptable under the Maastricht consensus which points out that rates consistently below 80% by intention-to-treat are not acceptable for treating H. pylori(Graham et al. 2007).
What antibiotics are used to treat H pylori ulcers?
H. pylori-caused ulcers are treated with a combination of antibiotics and an acid-reducing proton pump inhibitor. Antibiotics: Usually two antibiotics are prescribed. Among the common choices are amoxicillin, clarithromycin (Biaxin®), metronidazole (Flagyl®) and tetracycline.

Can H pylori cause stomach ulcers in children?​

H. pylori is a very common cause of peptic ulcers and gastritis in adults, but it can and does occur in children too. Call your pediatrician if your child has any symptoms suggestive of gastritis.
How does H pylori attack the stomach lining?
H. pylori attacks the lining that protects your stomach. The bacteria make an enzyme called urease. This enzyme makes your stomach acids less acidic. This weakens your stomach’s lining. Your stomach cells then have greater risk of being hurt by acid and pepsin, strong digestive fluids.

Does H pylori infection increase stomach cancer risk?​

If you have an _H. pylori _infection, you have an increased risk for stomach cancer later in life. If you have a strong family history of stomach cancer and other cancer risk factors, even though you may not have symptoms of a stomach ulcer, your healthcare provider may recommend being tested for H. pylori antibodies.